Detroit Lions at Buffalo Bills — Week 2 Odds, Injuries & Prediction
Detroit Lions @ Buffalo Bills: live odds, injury report, team rankings comparison, and win probability for this matchup.
Thu, Sep 17 · 8:15 PM ET · Prime Video
Final: Detroit Lions 31 - 41 Buffalo Bills. Buffalo Bills won. Model prediction was correct.
Odds (DraftKings): BUF -5.5 · ML DET +205 / BUF -250 · O/U 54.5
Model prediction
Predicted winner: Buffalo Bills - DET 25% / BUF 75%
Team stats comparison (rank out of 32)
| DET offense | BUF offense | Edge |
|---|
| Total yards | #12 | #6 | home edge (6) |
| Rush yards | #5 | #25 | away edge (20) |
| Pass yards | #15 | #4 | home edge (11) |
| DET defense | BUF defense | Edge |
|---|
| Total yards allowed | #29 | #23 | home edge (6) |
| Rush yards allowed | #11 | #20 | away edge (9) |
| Pass yards allowed | #32 | #25 | home edge (7) |
Injury report
- D.J. Reed (DET · CB) - active - Foot
- Christian Mahogany (DET · G) - questionable - Hip (knee injury that migrated to the hip)
- Blake Miller (DET · RT) - questionable - Knee
- DJ Moore (BUF · WR) - questionable - AC joint sprain (left shoulder)
- Brian Branch (DET · S) - out - Torn Achilles - on reserve/PUP
- Kerby Joseph (DET · S) - out - Knee injury (lingering from 2025) - on reserve/PUP
- Payton Turner (DET · DE) - out - Back
- Isiah Pacheco (DET · RB) - out - Back - surgery (loose body pressing on a nerve), on injured reserve
- Cade Mays (DET · C) - out - Fractured wrist - on injured reserve, designated to return
- Avonte Maddox (DET · CB) - out - Foot - season-ending surgery
- Tyrell Shavers (BUF · WR) - out - Knee - ACL
Detroit Lions full schedule ·
Buffalo Bills full schedule ·
See this week's full NFL odds and predictions on Blitz Odds