Buffalo Bills Schedule, Odds & Predictions
Buffalo Bills full 2026 schedule with matchup predictions, win probabilities, and injury report - powered by Blitz Odds' team-ranking model.
Buffalo Bills team stats (rank out of 32)
| Offense | Defense |
|---|
| Total yards | #2 | #28 |
| Rush yards | #5 | #12 |
| Pass yards | #4 | #30 |
Buffalo Bills 2026 schedule
| Week | Opponent | Date | Prediction | Result |
|---|
| Preseason Week 1 | vs Carolina Panthers | Sat, Aug 15 1:00 PM ET | Model predicts Buffalo Bills to win (81%) | W 29-14 (CAR 14 - 29 BUF, prediction correct) |
| Preseason Week 2 | @ Cleveland Browns | Sat, Aug 22 1:00 PM ET | Model predicts Buffalo Bills to win (74%) | W 31-7 (BUF 31 - 7 CLE, prediction correct) |
| Preseason Week 3 | vs Pittsburgh Steelers | Thu, Aug 27 7:00 PM ET | Model predicts Buffalo Bills to win (87%) | W 28-27 (PIT 27 - 28 BUF, prediction correct) |
| Week 1 | @ Houston Texans | Sun, Sep 13 1:00 PM ET | Model predicts Buffalo Bills to win (80%) | W 36-31 (BUF 36 - 31 HOU, prediction correct) |
| Week 2 | vs Detroit Lions | Thu, Sep 17 8:15 PM ET | Model predicts Buffalo Bills to win (75%) | W 41-31 (DET 31 - 41 BUF, prediction correct) |
| Week 3 | vs Los Angeles Chargers | Sun, Sep 27 1:00 PM ET | Model predicts Buffalo Bills to win (79%) | Not played yet |
| Week 4 | vs New England Patriots | Sun, Oct 4 1:00 PM ET | Model predicts Buffalo Bills to win (58%) | Not played yet |
| Week 5 | @ Los Angeles Rams | Mon, Oct 12 8:15 PM ET | Model predicts Los Angeles Rams to win (40%) | Not played yet |
| Week 6 | @ Las Vegas Raiders | Sun, Oct 18 4:25 PM ET | Model predicts Buffalo Bills to win (63%) | Not played yet |
| Week 7 | Bye week |
| Week 8 | vs Baltimore Ravens | Sun, Nov 1 1:00 PM ET | Model predicts Buffalo Bills to win (61%) | Not played yet |
| Week 9 | @ Minnesota Vikings | Mon, Nov 9 8:15 PM ET | Model predicts Buffalo Bills to win (87%) | Not played yet |
| Week 10 | @ New York Jets | Sun, Nov 15 1:00 PM ET | Model predicts Buffalo Bills to win (56%) | Not played yet |
| Week 11 | vs Miami Dolphins | Sun, Nov 22 1:00 PM ET | Model predicts Buffalo Bills to win (74%) | Not played yet |
| Week 12 | vs Kansas City Chiefs | Thu, Nov 26 8:20 PM ET | Model predicts Kansas City Chiefs to win (33%) | Not played yet |
| Week 13 | @ New England Patriots | Sun, Dec 6 4:25 PM ET | Model predicts Buffalo Bills to win (51%) | Not played yet |
| Week 14 | @ Green Bay Packers | Sun, Dec 13 8:20 PM ET | Model predicts Buffalo Bills to win (76%) | Not played yet |
| Week 15 | vs Chicago Bears | Thu, Dec 17 8:15 PM ET | Model predicts Buffalo Bills to win (76%) | Not played yet |
| Week 16 | @ Denver Broncos | Fri, Dec 25 4:30 PM ET | Model predicts Buffalo Bills to win (72%) | Not played yet |
| Week 17 | @ Miami Dolphins | Sun, Jan 3 1:00 PM ET | Model predicts Buffalo Bills to win (64%) | Not played yet |
| Week 18 | vs New York Jets | Sun, Jan 10 TBD | Model predicts Buffalo Bills to win (66%) | Not played yet |
Buffalo Bills injury report
- DJ Moore (WR) - questionable - AC joint sprain (left shoulder)
- Tyrell Shavers (WR) - out - Knee - ACL
See this week's full NFL odds and predictions on Blitz Odds