Denver Broncos at San Francisco 49ers — Week 4 Odds, Injuries & Prediction

Denver Broncos @ San Francisco 49ers: live odds, injury report, team rankings comparison, and win probability for this matchup.

Sun, Oct 4 · 4:25 PM ET · CBS

Odds (DraftKings): SF -2.5 · ML DEN +120 / SF -142 · O/U 46.5

Model prediction

Predicted winner: Denver Broncos - DEN 92% / SF 8%

Team stats comparison (rank out of 32)

	DEN offense	SF offense	Edge
Total yards	#10	#7	home edge (3)
Rush yards	#16	#24	away edge (8)
Pass yards	#11	#5	home edge (6)

	DEN defense	SF defense	Edge
Total yards allowed	#2	#20	away edge (18)
Rush yards allowed	#2	#11	away edge (9)
Pass yards allowed	#7	#25	away edge (18)

Injury report

• Christian McCaffrey (SF · RB) - questionable - Calf/leg tightness (undisclosed body part)
• Mike Evans (SF · WR) - questionable - Quad strain
• George Kittle (SF · TE) - out - Torn Achilles tendon
• Ricky Pearsall (SF · WR) - out - PCL knee surgery - season-ending
• Nick Bosa (SF · Edge) - out - Knee tendinitis (surgically repaired right knee)

Denver Broncos full schedule · San Francisco 49ers full schedule · See this week's full NFL odds and predictions on Blitz Odds