San Francisco 49ers Schedule, Odds & Predictions
San Francisco 49ers full 2026 schedule with matchup predictions, win probabilities, and injury report - powered by Blitz Odds' team-ranking model.
San Francisco 49ers team stats (rank out of 32)
| Offense | Defense |
|---|
| Total yards | #8 | #10 |
| Rush yards | #8 | #17 |
| Pass yards | #8 | #10 |
San Francisco 49ers 2026 schedule
| Week | Opponent | Date | Prediction | Result |
|---|
| Preseason Week 1 | vs Tennessee Titans | Thu, Aug 13 9:00 PM ET | Model predicts Tennessee Titans to win (37%) | L 13-19 (TEN 19 - 13 SF, prediction correct) |
| Preseason Week 2 | @ Los Angeles Chargers | Thu, Aug 20 10:00 PM ET | Model predicts Los Angeles Chargers to win (22%) | W 41-17 (SF 41 - 17 LAC, prediction missed) |
| Preseason Week 3 | @ Las Vegas Raiders | Thu, Aug 27 8:00 PM ET | Model predicts Las Vegas Raiders to win (35%) | W 18-12 (SF 18 - 12 LV, prediction missed) |
| Week 1 | @ Los Angeles Rams | Thu, Sep 10 8:35 PM ET | Model predicts Los Angeles Rams to win (14%) | W 27-7 (SF 27 - 7 LAR, prediction missed) |
| Week 2 | vs Miami Dolphins | Sun, Sep 20 4:25 PM ET | Model predicts Miami Dolphins to win (31%) | W 35-13 (MIA 13 - 35 SF, prediction missed) |
| Week 3 | vs Arizona Cardinals | Sun, Sep 27 4:05 PM ET | Model predicts Arizona Cardinals to win (50%) | Not played yet |
| Week 4 | vs Denver Broncos | Sun, Oct 4 4:25 PM ET | Model predicts Denver Broncos to win (45%) | Not played yet |
| Week 5 | @ Seattle Seahawks | Sun, Oct 11 4:25 PM ET | Model predicts Seattle Seahawks to win (23%) | Not played yet |
| Week 6 | vs Washington Commanders | Mon, Oct 19 8:15 PM ET | Model predicts San Francisco 49ers to win (53%) | Not played yet |
| Week 7 | @ Atlanta Falcons | Sun, Oct 25 1:00 PM ET | Model predicts Atlanta Falcons to win (29%) | Not played yet |
| Week 8 | Bye week |
| Week 9 | vs Las Vegas Raiders | Sun, Nov 8 4:05 PM ET | Model predicts Las Vegas Raiders to win (32%) | Not played yet |
| Week 10 | @ Dallas Cowboys | Sun, Nov 15 4:25 PM ET | Model predicts Dallas Cowboys to win (45%) | Not played yet |
| Week 11 | vs Minnesota Vikings | Sun, Nov 22 8:20 PM ET | Model predicts San Francisco 49ers to win (63%) | Not played yet |
| Week 12 | vs Seattle Seahawks | Sun, Nov 29 4:25 PM ET | Model predicts Seattle Seahawks to win (32%) | Not played yet |
| Week 13 | @ New York Giants | Sun, Dec 6 1:00 PM ET | Model predicts New York Giants to win (45%) | Not played yet |
| Week 14 | vs Los Angeles Rams | Sun, Dec 13 4:25 PM ET | Model predicts Los Angeles Rams to win (15%) | Not played yet |
| Week 15 | @ Los Angeles Chargers | Thu, Dec 17 8:15 PM ET | Model predicts Los Angeles Chargers to win (45%) | Not played yet |
| Week 16 | @ Kansas City Chiefs | Sun, Dec 27 4:25 PM ET | Model predicts Kansas City Chiefs to win (4%) | Not played yet |
| Week 17 | vs Philadelphia Eagles | Sun, Jan 3 8:20 PM ET | Model predicts Philadelphia Eagles to win (36%) | Not played yet |
| Week 18 | @ Arizona Cardinals | Sun, Jan 10 TBD | Model predicts Arizona Cardinals to win (39%) | Not played yet |
San Francisco 49ers injury report
- Mike Evans (WR) - questionable - Hip
- Ricky Pearsall (WR) - out - PCL knee surgery - season-ending
- Nick Bosa (Edge) - out - Calf
- Christian Kirk (WR) - out - Calf
- Sam Okuayinonu (DE) - out - Foot injury - on injured reserve
- Romello Height (DE) - out - Hand
- Alfred Collins (DT) - out - Torn patellar tendon (knee) - season-ending
- De'Zhaun Stribling (WR) - out - Ankle - deltoid sprain, surgically repaired - on injured reserve
- Jake Tonges (TE) - out - MCL knee injury - on injured reserve, season-ending
- Demarcus Robinson (WR) - out - High ankle sprain
- Brandon Aiyuk (WR) - out - Personal
See this week's full NFL odds and predictions on Blitz Odds