San Francisco 49ers Schedule, Odds & Predictions
San Francisco 49ers full 2026 schedule with matchup predictions, win probabilities, and injury report - powered by Blitz Odds' team-ranking model.
San Francisco 49ers team stats (rank out of 32)
| Offense | Defense |
|---|
| Total yards | #7 | #20 |
| Rush yards | #24 | #11 |
| Pass yards | #5 | #25 |
San Francisco 49ers 2026 schedule
| Week | Opponent | Date | Prediction | Result |
|---|
| Preseason Week 1 | vs Tennessee Titans | Thu, Aug 13 9:00 PM ET | Model predicts Tennessee Titans to win (47%) | TEN 19 - 13 SF (L, prediction correct) |
| Preseason Week 2 | @ Los Angeles Chargers | Thu, Aug 20 10:00 PM ET | Model predicts Los Angeles Chargers to win (13%) | Not played yet |
| Preseason Week 3 | @ Las Vegas Raiders | Thu, Aug 27 8:00 PM ET | Model predicts Las Vegas Raiders to win (35%) | Not played yet |
| Week 1 | @ Los Angeles Rams | Thu, Sep 10 8:35 PM ET | Model predicts Los Angeles Rams to win (9%) | Not played yet |
| Week 2 | vs Miami Dolphins | Sun, Sep 20 4:25 PM ET | Model predicts Miami Dolphins to win (37%) | Not played yet |
| Week 3 | vs Arizona Cardinals | Sun, Sep 27 4:05 PM ET | Model predicts Arizona Cardinals to win (41%) | Not played yet |
| Week 4 | vs Denver Broncos | Sun, Oct 4 4:25 PM ET | Model predicts Denver Broncos to win (8%) | Not played yet |
| Week 5 | @ Seattle Seahawks | Sun, Oct 11 4:25 PM ET | Model predicts Seattle Seahawks to win (7%) | Not played yet |
| Week 6 | vs Washington Commanders | Mon, Oct 19 8:15 PM ET | Model predicts San Francisco 49ers to win (52%) | Not played yet |
| Week 7 | @ Atlanta Falcons | Sun, Oct 25 1:00 PM ET | Model predicts Atlanta Falcons to win (24%) | Not played yet |
| Week 8 | Bye week |
| Week 9 | vs Las Vegas Raiders | Sun, Nov 8 4:05 PM ET | Model predicts Las Vegas Raiders to win (39%) | Not played yet |
| Week 10 | @ Dallas Cowboys | Sun, Nov 15 4:25 PM ET | Model predicts Dallas Cowboys to win (19%) | Not played yet |
| Week 11 | vs Minnesota Vikings | Sun, Nov 22 8:20 PM ET | Model predicts Minnesota Vikings to win (24%) | Not played yet |
| Week 12 | vs Seattle Seahawks | Sun, Nov 29 4:25 PM ET | Model predicts Seattle Seahawks to win (8%) | Not played yet |
| Week 13 | @ New York Giants | Sun, Dec 6 1:00 PM ET | Model predicts New York Giants to win (29%) | Not played yet |
| Week 14 | vs Los Angeles Rams | Sun, Dec 13 4:25 PM ET | Model predicts Los Angeles Rams to win (10%) | Not played yet |
| Week 15 | @ Los Angeles Chargers | Thu, Dec 17 8:15 PM ET | Model predicts Los Angeles Chargers to win (13%) | Not played yet |
| Week 16 | @ Kansas City Chiefs | Sun, Dec 27 4:25 PM ET | Model predicts Kansas City Chiefs to win (17%) | Not played yet |
| Week 17 | vs Philadelphia Eagles | Sun, Jan 3 8:20 PM ET | Model predicts Philadelphia Eagles to win (37%) | Not played yet |
| Week 18 | @ Arizona Cardinals | Sun, Jan 10 TBD | Model predicts Arizona Cardinals to win (37%) | Not played yet |
San Francisco 49ers injury report
- Christian McCaffrey (RB) - questionable - Calf/leg tightness (undisclosed body part)
- Mike Evans (WR) - questionable - Quad strain
- George Kittle (TE) - out - Torn Achilles tendon
- Ricky Pearsall (WR) - out - PCL knee surgery - season-ending
- Nick Bosa (Edge) - out - Knee tendinitis (surgically repaired right knee)
See this week's full NFL odds and predictions on Blitz Odds