San Francisco 49ers at Los Angeles Chargers — Preseason Week 2 Odds, Injuries & Prediction

San Francisco 49ers @ Los Angeles Chargers: live odds, injury report, team rankings comparison, and win probability for this matchup.

Thu, Aug 20 · 10:00 PM ET · NFL Network

Final: San Francisco 49ers 41 - 17 Los Angeles Chargers. San Francisco 49ers won. Model prediction was incorrect.

Odds (DraftKings): SF -1.5 · ML SF -112 / LAC -108 · O/U 38.5

Model prediction

Predicted winner: Los Angeles Chargers - SF 33% / LAC 67%

Blitz Edge: why the model likes Los Angeles Chargers

The model gives Los Angeles Chargers a 67% chance to win this one. The biggest factors: LAC's rush defense (#8) has a 16-spot edge over SF's rush offense (#24), and LAC's total offense (#12) has a 8-spot edge over SF's total defense (#20).

Home field adds a small extra boost on top of that. SF is also dealing with Nick Bosa (Edge) listed as out, which tips things further LAC's way. Note: the sportsbook favorite (SF) disagrees with this pick.

Team stats comparison (rank out of 32)

	SF offense	LAC offense	Edge
Total yards	#7	#12	away edge (5)
Rush yards	#24	#12	home edge (12)
Pass yards	#5	#18	away edge (13)

	SF defense	LAC defense	Edge
Total yards allowed	#20	#5	home edge (15)
Rush yards allowed	#11	#8	home edge (3)
Pass yards allowed	#25	#5	home edge (20)

Injury report

Ladd McConkey (LAC · WR) - questionable - Foot
Ricky Pearsall (SF · WR) - out - PCL knee surgery - season-ending
Nick Bosa (SF · Edge) - out - Calf
Christian Kirk (SF · WR) - out - Calf
Sam Okuayinonu (SF · DE) - out - Foot injury - on injured reserve
Alfred Collins (SF · DT) - out - Torn patellar tendon (knee) - season-ending
De'Zhaun Stribling (SF · WR) - out - Ankle - deltoid sprain, surgically repaired - on injured reserve
Jake Tonges (SF · TE) - out - MCL knee injury - on injured reserve, season-ending
Demarcus Robinson (SF · WR) - out - High ankle sprain
Brandon Aiyuk (SF · WR) - out - Personal
Rashawn Slater (LAC · LT) - out - Ankle
Tyler Biadasz (LAC · C) - out - Torn ACL - season-ending
Dalevon Campbell (LAC · WR) - out - Leg
KeAndre Lambert-Smith (LAC · WR) - out - Hamstring
David Njoku (LAC · TE) - out - Fibula (lower leg) - on injured reserve
Charlie Kolar (LAC · TE) - out - Broken forearm - surgery, on injured reserve
Brenen Thompson (LAC · WR) - out - Quadriceps

San Francisco 49ers full schedule · Los Angeles Chargers full schedule · See this week's full NFL odds and predictions on Blitz Odds